Updating the natural history of hpv and anogenital cancer what makes a guy intimidating
Firstly, seroprevalence is likely to underestimate the proportion of women who have had an HPV infection, since other studies have suggested that only 65–90 of HPV DNA-positive female subjects seroconvert, with differences in estimates depending on factors including the testing systems used, how long HPV DNA persists and whether or not there is progression to disease (Dillner, 1999; Carter et al, 2000).
Seroconversion may coincide with DNA detection, or may follow by some months; for example, one study found a delay in seroconversion of 6–12 months after HPV 16 infection, with type-specific variation seen in the time to seroconversion (Carter et al, 2000).
Epidemiological knowledge of HPV infection in the UK relies heavily on prevalence studies of HPV DNA in the cervical epithelium of women undergoing cervical sampling (Woodman et al, 2001; Kitchener et al, 2006) and usually relates to female subjects known to be sexually active.
These studies indicate the prevalence of current infection, as most HPV infections are transient and become DNA negative within 2 years (Moscicki et al, 2006).
of cases of anogenital warts (von Krogh et al, 2001).